I feel very discouraged. I worked my butt off and supported our family through internship, residency and two fellowships always looking forward to the day when he would finally be in practice and things would get 'easier". It sounds like you two haven't gotten exceptionally close and that it wouldn't be too hard on either of you to jump ship and move on.
Recently though she has been quite distant, although this may be due to a combination of reasons - such as family sickness and now being on nights.
I have been a doctor's wife for almost 2 years - and we have been together for about 7 years, since right before intern year.